The lab is part of the Center for Cellular and Molecular Therapeutics at CHOP and the Department of Genetics at the University of Pennsylvania. 

Our lab is interested in functional genomics, approaches that are aimed at understanding gene function by following the effects of direct perturbations at a large scale, we are developing novel perturbation and functional genomics approaches and applying them together with additional genomics approaches to study a range of human diseases including early and late onset neurodegenerative diseases.

Shalem Lab

Functional Genomics

Protein Quality Control

and Neurodegeneration